Agent Architecture/Domain-Specific Agents
Advanced14 min

Agents for Healthcare

Building production agents for clinical decision support, patient documentation, and medical Q&A — with HIPAA compliance, safety guardrails, and the principle that AI assists clinicians but never replaces clinical judgment.

Quick Reference

  • HIPAA compliance requires a BAA with your LLM provider — no BAA means no PHI in prompts, period
  • Never replace clinical judgment: the agent suggests, the clinician decides
  • Cite medical literature (PubMed, UpToDate) for every clinical claim — reject uncited outputs
  • Implement emergency detection that immediately escalates life-threatening queries to a human
  • PII middleware must strip PHI from logs, traces, and any data sent to third-party services

HIPAA Compliance Architecture

HIPAA is not a suggestion — it is a federal requirement with penalties up to $1.5M per violation category per year. Before you write a single line of agent code, you need the compliance infrastructure in place. The most critical piece: a Business Associate Agreement (BAA) with every vendor that touches Protected Health Information (PHI).

ComponentHIPAA RequirementImplementation
LLM ProviderBAA required if PHI is in promptsUse Azure OpenAI or AWS Bedrock (BAA available); or strip PHI before calling the API
Vector databaseBAA required if storing PHI embeddingsSelf-host Qdrant/Weaviate or use a HIPAA-compliant managed service
Logging / tracingPHI must not appear in logsPII middleware strips PHI before logging; use audit-grade storage
Data at restEncryption required (AES-256)Encrypt vector stores, databases, and file storage
Data in transitTLS 1.2+ requiredEnforce HTTPS everywhere; no plaintext API calls
Access controlMinimum necessary standardRole-based access; clinicians see only their patients' data
PII middleware — strips PHI before the prompt reaches the LLM
No BAA = No PHI

If your LLM provider does not offer a BAA, you cannot send PHI in prompts. Period. Use the PII middleware to strip all PHI before the API call, and restore it in the response for authorized users only.